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diagnosis differential hematology management causes oncology treatment vasculitis algorithm anemia dermatology chronic classification hemolysis hivaids idsa leukemia night opportunistic prevention
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
x (Hct / 45) / Maturation ... Factor The maturation ... (e.g. cancer, infection ... suppression (e.g. drugs ... G6PD deficiency), Infections
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
methotrexate) • Drugs ... anti-HLA antibodies Drugs ... Non-lmmune: • HELLP Syndrome ... Vasculitis • Infection ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Transfusion reactions, Drug-associated ... , PCH, Evans Syndrome ... Membrane Defects, Drugs ... Internal (RBC) - Infections ... Differential #Diagnosis #hematology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal Syndrome ... Disease • Other: Drugs ... allopurinol), Infection ... Investigations • Labs: CBC ... DAH, rule out infection
Causes of Pericardial Effusion - Differential Diagnosis Infectious: • Viral: Enterovirus, Herpesvirus, Adenovirus, Parvovirus • Bacterial: Mycobacterium
Differential Diagnosis Infectious ... , Candida Non-Infectious ... : • Rheumatologic ... Disease, Behcet Syndrome ... Dissection, Idiopathic, Drug-related
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... Mycoplasma pneumoniae infection ... ) - Drugs ( ... spherocytosis) • Infections
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Churg-Strauss syndrome ... angiitis induced by drugs ... malignomas, and infectious ... - Sjögren syndrome ... Vessels #Diagnosis #Rheumatology
Causes of Fat Malabsorption - Differential Diagnosis Biliary Duct Obstruction • Autoimmune— PBC, PSC • Infection— liver
— PBC, PSC • Infection ... • Cholestatic drugs ... Shwachman-Diamond syndrome ... disease • IBD- CD ... • Short bowel syndrome
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... →Activation of CD8 ... Still disease, Infection ... immune deficiency, Drugs ... treatment #summary #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Secondary Causes: - Drug ... SLE) - Viral infections ... Kasabach-Merritt syndrome ... spotted fever • Drug ... #rheumatology #
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