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causes algorithm chronic cll hodgkins lymphocytic lymphoma mds myelodysplastic aplastic calculation comparison erythematosus hemeonc lupus myelodysplasia nonhodgkins nonpalpable palpable pancytopenia
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
) - Differential ... Diagnosis Algorithm ... Inflammation, Chronic Infection ... #MCV #Classification ... #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
x (Hct / 45) / Maturation ... Factor The maturation ... #hematology #anemia ... #differential # ... diagnosis #calculation
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
• Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Cancer: • Leukemia ... Infections: ... #Diagnosis #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... Non-lmmune: • HELLP Syndrome ... Vasculitis • Infection ... #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Difficulty breathing • Neutropenia ... virus (EBV) • Leukemia ... • Reticulocyte index ... #oncology #hematology ... #diagnosis #management
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... specifically: iron deficiency ... Myelodysplastic syndrome ... Chronic myeloid leukemia ... #hematology #secondary
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... risk-stratification • Risks: infection ... transformation to acute leukemia ... #hematology #oncology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential ... Diagnosis Neonate ... Megaloblastic anemia-rare ... - Copper deficiency-rare ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... necrosis) • VIT K deficiency ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
all phases of maturation ... - infiltrates (anemia ... or functional neutropenia ... #Hematology #Oncology ... #Diagnosis
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