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diagnosis management anemia differential mds myelodysplastic syndrome algorithm centralretinalartery chronic coagulation crao dermatology dic disseminated intravascular lymphocytic myelodysplasia neutropenia occlusion
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic ... Leukemia, Tumour ... ITP • SLE • CLL ... #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... -> AML: Blast crises ... phases of maturation ... Phosphorus CLL ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... aplasia • ITP ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Consider stem cell ... to MDS or acute leukemia ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... transformation to acute leukemia ... Allogeneic stem cell ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... virus (EBV) • Leukemia ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Anemia • Aplastic ... Leukemia • Idiopathic ... • Copper deficiency ... Syndromes #diagnosis #hematology ... #oncology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
anti-coagulation • Hematologic ... Disease: (i.e. leukemia ... retinal edema caused ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis #signs
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... protein C and S Pathophysiology ... thrombopoietin deficiency ... Treat primary cause ... #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Episcleritis Signs ... general feeling of ill ... Causes: - Idiopathic ... Treatment: - Systemic ... #oncology
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