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Iron Deficiency Anemia vs Anemia of Chronic Disease - Laboratory Testing

SUMMARY:
 - RDW, FEP, serum iron,
Iron Deficiency ... of Chronic Disease ... , saturation-worthless ... #Deficiency #Anemia ... #Chronic #Disease
Iron Panel Interpretation

Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation,  ↓
Iron deficiency ... , ↓ Ferritin Anemia ... of chronic inflammation ... deficiency + Chronic ... differential #hematology #laboratory
For an elderly patient with multiple comorbidities it can be challenging to determine if their anemia
deficiency as well ... as anemia of chronic ... disease. ... #Deficiency #Anemia ... #Transferrin #Saturation
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (<80 fL) • Iron ... of Chronic Disease ... of Chronic Disease ... Diagnosis #Algorithm #Causes
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Thalassemia, Iron ... deficiency anemia ... , Chronic disease ... elliptocytosis, Severe iron ... deficiency anemia
Gastrointestinal Evaluation of Iron Deficiency Anemia
In patients with anemia, diagnose iron deficiency if:
 • Ferritin <
Deficiency Anemia ... • Additional laboratory ... inflammation or chronic ... Test for celiac disease ... #Deficiency #Anemia
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
Algorithm - Iron ... deficiency anemia ... - Anemia of chronic ... of chronic kidney ... disease - Vitamin
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
x (Hct / 45) / Maturation ... Factor The maturation ... deficiencies: Iron ... kidney disease, ... , G6PD deficiency
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Microcytic" • Iron ... deficiency • ... disease, Acute ... Alcohol use, Liver disease ... differential #diagnosis #causes
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
Causes of False ... RBC turnover • Iron ... -12, or folate deficiency ... • Hemolytic anemia ... End-stage renal disease