30 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... count ↑ PLT • ↑ PBS ... phases of maturation ... #Hematology #Oncology ... #Diagnosis
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases

Acanthocyte (spur cell),  
Basophilic stippling, 
Bite cell,
and Associated Diseases ... Morphologies #Key #Atlas ... Microscopy #Pathology #Hematology ... #Diagnosis #Dyspmorphic ... Pathologic Basis of Disease
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Atlas • Microcytic ... - Iron-deficiency ... #Morphology #Atlas ... #key #diagnosis ... #differential #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Thalassemia, Iron ... elliptocytosis, Severe iron ... #differential #diagnosis ... #hematology #microscopy ... #atlas #nomenclature
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Artifact (redo CBC ... Chronic Myelogenous Leukemia ... disorders • Celiac disease ... malignancy • Iron ... Algorithm #Causes #Hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
- Differential Diagnosis ... Colitis and Crohn’s Disease ... Other Causes: • Iron ... Irradiation • Cirrhosis ... #causes #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Diagnosis: • ... cells can indicate disease ... leukemia #CLL ... #oncology #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
- Differential Diagnosis ... Congestive • Cirrhosis ... • Lymphoma • Leukemia ... • Sickle Cell ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Factor The maturation ... deficiencies: Iron ... Chronic kidney disease ... Production #Index #hematology ... #differential #diagnosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Clinical features ... involved) • No leukemic ... Differential Diagnosis ... Lymphomas • Other hematologic ... #differential #hematology