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differential hemolytic algorithm autoimmune causes symptoms disease extravascular intravascular anemias anorexianervosa antiglobulin behcet classification complications dat direct management monoclonal oncology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Agglutinin Disease ... #Anemia #AIHA # ... #Table #hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... - Warm vs Cold ... #Anemia #Pathophysiology ... #diagnosis #hematology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs ... of anemia and hemolysis ... Anemias (AIHAs) ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... )"Cold" (usually ... agglutin disease ... #hematology #anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin ... Diagnosis: • hemolytic ... anemia • Cold ... #hemolytic #anemia ... #hematology #diagnosis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... • Cold AIHA ... anemia • ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
), C3d ( - ) WAIHA ... , C3d ( +/- ) Cold ... agglutinin disease ... ) Paroxysmal cold ... #hematology #diagnosis
Pathophysiology, Signs and Symptoms of Hemolytic Anemia #Pathophysiology #Hemolytic #Anemia #hematology #diagnosis #signs #symptoms
Pathophysiology, ... Signs and Symptoms ... of Hemolytic Anemia ... #Hemolytic #Anemia ... #hematology #diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... , Cold AIHA, Transfusion ... Defects: Sickle cell anemia ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... Agglutination - Cold ... agglutinins disease ... #workup #hematology
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