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diagnosis differential hematology allergy reactions hypersensitivity management table workup aafp antibiotics antibody autoimmune blood comparison conjugated definitions endocrinology extravascular extrinsic
Hemolysis Classification - Intrinsic and Extrinsic Causes Commentary: Another way to think of immune hemolysis would be
Hemolysis Classification ... think of immune hemolysis ... IVIG-mediated hemolysis ... , hemolytic transfusion ... #Algorithm
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Hypersensitivity: Summary Type ... conjunctivitis Type ... thrombocytopenia, Autoimmune Hemolytic ... anemia, Penicillin-induced ... #Types #Classification
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... haptogbbulin #Hemolysis ... #Hemolytic #Anemia ... #Causes #Workup
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
Hours to Days (Hemolytic ... Anemia) Type ... Rash, SJS) - Amelia ... #Classification ... #Allergy #Diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Immune mediated hemolysis ... Microangiopathic hemolytic ... UnremarkableLab #Hemolytic ... #causes
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... reticulocytes • Hemolysis ... Coombs • IgG type ... 2) LOOK FOR a cause ... Antibody #Autoimmune #Hemolytic
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... immune-complex hemolytic ... malformations #Hemolysis
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Differential Diagnosis Algorithm ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... #Causes #Hematology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
When the specific allergen ... hay fever, food allergies ... , and drug allergies ... or during hemolytic ... #Classification
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Differential Diagnosis Algorithm ... • Bleeding • Hemolysis ... #MCV #Classification ... #Causes #Hematology
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