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When trying to differentiate between the two conditions think “FAST” with Serotonin Syndrome and “SLOW” with
When trying to differentiate ... think “FAST” with Serotonin ... Syndrome and “SLOW ... Serotonin Syndrome ... #Diagnosis #Serotonin
Serotonin Syndrome Drug Precipitants and Pharmacology
↑ Serotonin Formation: Tryptophan, Oxitriptan
↑ Serotonin Release: Amphetamines, Cocaine, Mirtazapine
↑ Serotonin
Serotonin Syndrome ... Pharmacology ↑ Serotonin ... #Syndrome #Pharmacology ... #medications #causes ... #differential #
Serotonin Syndrome - THINK: FAST
 - FAST onset
 - FAST movements (agitation, akathisia, HYPERreflexia)
 - FAST
Serotonin Syndrome ... Neuroleptic Malignant Syndrome ... - THINK: SLOW ... NeurolepticMalignant #Syndrome ... Toxicology #Comparison #Differentiate
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Normal Acid-Base: Low ... #Hypokalemia #Differential ... causes #potassium #low ... #nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Injury (AKI) - Differential ... Abdominal Compartment Syndrome ... , Medications Intra-Renal ... Kidney #Injury #Differential ... #Diagnosis #nephrology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... • Refeeding syndrome ... Thyrotoxicosis Medications ... vomiting) • Low ... Diagnosis #Algorithm #nephrology
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Hypomagnesemia - Differential ... and Gitelman syndrome ... Hypomagnesemia - Acquired: Medications ... diagnosis #causes #nephrology ... #magnesium #low
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Shock - Differential ... Failure, Toxins/Medications ... Abdominal compartment syndrome ... #Diagnosis #criticalcare ... algorithm #treatment #management
Management of Serotonin Syndrome
Identify and stop all serotoninergic medications
 • Avoid inadvertent Rx of serotoninergic meds
Management of Serotonin ... Syndrome Identify ... serotoninergic medications ... Medicine @ucsdim #Serotonin ... #Syndrome #Management
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Metabolic Alkalosis - Differential ... hyperaldosteronism • Low ... , NGT suction, Low ... Metabolic #Alkalosis #Differential ... Diagnosis #Algorithm #nephrology