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causes hepatology aflp aiha algorithm atlas bloodcell calculation classification coagulation extravascular hepatitis icp index intravascular liver microscopy morphology nomenclature nonpalpable
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - ... coagulation (DIC) - HELLP ... Defects: Enzyme deficiencies ... G6PD deficiency) ... #diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Differential Diagnosis ... #Hemolytic #Anemia ... #Diagnosis #Table ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hemolysis) ARUPConsult ... @ARUPLabs #Hemolytic ... #Anemia #Differential ... #workup #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
’s anemia • Wiskott-Aldrich ... Inflammatory and Autoimmune ... Antibody-mediated hemolysis ... Nutritional Deficiencies ... #Diagnosis #Hematology
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework LOW RETIC INDEX - ↓ PRODUCTION • Vitamin
Differential Diagnosis ... , Autoimmune hemolytic ... anemia, Hemolysis ... #Cirrhosis #Differential ... #Diagnosis #Hepatology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... hemolytic anemia ... autoimmune hemolytic ... RBC #Morphology #differential ... #diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... udaygulati #Hemolytic ... #Anemia #Differential ... classification #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Anticoagulant Medications ... Septic shock, Obstetric ... #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Chronic kidney disease ... Retroperitoneal, Uterine • Hemolysis ... hemolytic anemia ... Production #Index #hematology ... #anemia #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... TTP, HUS, DIC, HELLP ... : Warm AIHA, Cold ... Urobilinogen #Hemolysis ... Diagnosis #hematology
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