23 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... - Differential ... Hypersplenism, Infection ... #Anemias #Differential ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
- Differential ... ): • Acute infection ... malignancies • Anemia ... iron deficiency, hemolysis ... #Differential #
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - ... Differential Diagnosis ... Reactive: • Anemia ... #Differential # ... causes #Platelets #hematology
Causes of Hemolytic Anemia - Differential Diagnosis
Inherited
 • Membrane
 • Internal
    - Hemoglobin
Causes of Hemolytic ... Anemia - Differential ... Internal - Infectious ... #Anemia #Differential ... Diagnosis #Causes #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... spherocytosis) • Infections ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... Platelet Count - Differential ... blood loss, Acute hemolysis ... , deficiency anemia ... #Platelets #Differential
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
- Differential ... Myelofibrosis Infectious ... Iron deficiency anemia ... #Differential # ... Algorithm #Causes #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential ... circulation - Infections ... anemia • ... Extravascular #Differential ... Algorithm #Causes #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential ... -100): • Non-hemolytic ... , CKD • Hemolytic ... Macroangiopathic, Infections ... #Diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
(e.g. cancer, infection ... Microangiopathic hemolytic ... G6PD deficiency), Infections ... Production #Index #hematology ... #anemia #differential