19 results
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care

TRICC - NEJM 1999 -
- NEJM 2011 - Hip ... blood is a liquid ... Blood saves lives ... Transfusions are ... #Thresholds #Hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Hemolysis on labs ... May have drop in Hct ... Extremely rare - HIV ... diagnosis #management #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... • Febrile Non-Hemolytic ... May have drop in Hct ... Extremely rare - HIV ... diagnosis #management #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Diagnosis for Hemolytic ... Bartonella, Babesia ... prosthetic valve • Transfusion ... udaygulati #Hemolytic ... classification #hematology
Babesiosis - Babesia Life Cycle
1) Tick takes a blood meal (sporozoites introduced into host)
2) Trophozie ←→
Babesiosis - Babesia ... ) Tick takes a blood ... transfusion ... #Babesiosis #Babesia ... LifeCycle #diagnosis #pathophysiology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
of high parity blood ... donor • Pathophysiology ... : 2 hit mechanism ... • Pathophysiology ... #Reactions #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... AIHA, Cold AIHA, Transfusion ... - Peripheral Blood ... Urobilinogen #Hemolysis ... Differential #Diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... spherocytosis, Hemolytic ... anemia, Post transfusion ... Schistocytes - Hemolytic ... #differential #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
= (Retic %) x (Hct ... long (in days) it ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... Production #Index #hematology
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
..A peripheral-blood ... anemia, a form of hemolytic ... inflexible and prone to hemolysis ... resolve despite blood ... transfusions...