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Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
Thrombotic Microangiopathy ... - TTP VS HUS ... implications : TTP ... confirmatory testing for TTP ... #Thrombotic #Microangiopathy
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table • Thrombotic Thrombocytopenic Purpura (TTP)
Primary Thrombotic Microangiopathy ... Thrombocytopenic Purpura (TTP ... Primary #Thrombotic #Microangiopathy
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
Thrombotic Microangiopathy ... TMA is due to TTP ... compliment-mediated TTP ... TTP is only TMA ... #Thrombotic #Microangiopathy
Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Diagnosis of TTP: • Rare and severe, ADAMTS13 deficiency • Autoimmune
Thrombocytopenic Purpura (TTP ... Diagnosis of TTP ... • Distinguish TTP ... TMA: Thrombotic microangiopathy ... Treatment of TTP
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Mechanical Trauma (Microangiopathic ... - Thrombotic microangiopathy ... thrombocytopenic purpura (TTP
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Consumption: - Microangiopathy ... : DIC, TTP, HUS ... Antibody-mediated: ITP
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
microangiopathies (TMA) - TTP ... Drug-induced thrombotic microangiopathy
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Schistocytes: Microangiopathic ... DIC, TTP, HUS)
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Schistocytes DAT(-) → Microangiopathic ... hemolytic anemia (TTP
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
urinalysis 3) microangiopathic ... PLEX (overlap TTP
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