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Crystal cast in patient with AKI and TLS on Urine Microscopy

Randy Luciano MD, PhD @RandyLucianoMD

#TLS #Crystal
Crystal cast in ... patient with AKI ... and TLS on Urine ... Microscopy Randy ... #Crystal #casts
Atlas of Urine Microscopy Findings
 • Epithelial cells - Normal
 • Renal tubular cells - Acute
Atlas of Urine Microscopy ... • Red cell casts ... • White cell casts ... infection • Hyaline casts ... disease • Granular casts
Algorithmic Approach to Acute Interstitial Nephritis
When to suspect AIN? (not sensitive)
 • AKI, AKD, rapidly progressive
sensitive) • AKI ... sterile pyuria, WBC casts ... eosinophiluria, microscopic ... proteinuria, granular casts ... /RTE; blend sediment
Simplified Approach to Acute Kidney Injury (AKI)
1) IS THIS AN EMERGENCY? 
Is there a dialysis indication
cases are caused ... IMPROVEMENT If the urine ... Assess UA w/ microscopy ... for WBCs, RBCs, casts ... , crystals, protein
Urinalysis & Urine Sodium 
Theophilus Protospatharius, a seventh-century physician who wrote the first manuscript focused exclusively
urine sediment ... Microscopic exam ... • Urinary casts ... (AKI) FE Na < ... #UNa #casts #glucosuria
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... in creatinine by ... Epithelial cell casts ... myeloma) • Urate crystals ... polyangiitis /microscopic
Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
Guide to Acute Kidney ... - Urinalysis/microscopy ... UOP/weights - Urine ... uric acid (rhabdo/TLS ... ) Causes of
Urine Microscopy - Urinary Sediment Examination Instructions
Preparation of the urine for microscopic examination:
 • Clean catch
Urine Microscopy ... up by cells or casts ... Ill stain) and crystals ... RBC's, lipids, crystals ... protein matrix of casts
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
hepatitis, or acute ... (no casts, protein ... causes (esp. ... all cases. ... Hepatorenal #Syndrome #Hepatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... polarized light microscopy ... Screening Tests for Acute ... • Serum and urine ... diagnosis #testing #Rheumatology