718 results
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Erythematosus (SLE ... retroviruses), Drugs (minocycline ... Erythematosus #SLE
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... PTU (50%) and minocycline ... Erythematosus (SLE ... are evocative of SLE ... management of SLE
Drug Induced Systemic Lupus Erythematosus
> 100 drugs have been associated with drug-induced SLE
High risk (>5%):
 •
with drug-induced SLE ... Chlorpromazine, Isoniazid, Minocycline ... #DrugInduced #SLE
Causes of Fever: IMADE Mnemonic
INFECTION
 • Infection 1.0 - Common & Localizing: Base Rate
 • Infection
AUTOIMMUNE • SLE ... sulfasalzine. vancomycin, minocycline
Antibiotics with MRSA Coverage

Oral: Doxycycline, Minocycline, Clindamycin, TMP-SMX
IV: Vancomycin, Daptomycin, Telavancin, Ceftaroline, Dalbavancin, Oritavancin, Tigecycline
Oral and
: Doxycycline, Minocycline
Differential Diagnosis of Pulmonary Eosinophilia
Infection:
 • Helminthic: Loffler syndrome (Ascaris, hookworm, Strongyloides), Tropical pulmonary eosinophilia (lymphatic
Sulfonamides, Ampicillin, Minocycline
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Association with both SLE ... Anti-Ribo-P 5-15% If SLE ... higly specific for SLE ... patients with typical SLE
Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Erythematosus (SLE ... Erythematosus #SLE
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Spondyloarthropathies, SLE ... retinal exudates) - SLE ... nodules - RA, SLE ... disease - RA - SLE ... • Seizures - SLE
Effect of Selected Diseases on Complement Levels - C3, C4
 • SLE C3 ↓ C4 ↓↓
Levels - C3, C4 • SLE ... • Infection eg SBE