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hematology differential workup classification extravascular intravascular management thrombocytosis agglutinin cold common cvid disease endocrinology enlarged gout hodgkins hyperuricemia hypogammaglobulinemia immunodeficiency
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... haptogbbulin #Hemolysis ... #Hemolytic #Anemia ... #Hematology #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - ... Intravascular Hemolysis ... usually IgM) (e.g. primary ... lymphoproliferative disorders ... #hematology #anemia
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Reticulocytosis • Primary ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... #Algorithm #Causes
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... immune-complex hemolytic ... #Algorithm #Causes
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider RBC membrane disorder ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... #Diagnosis #Algorithm
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... Post-splenectomy Primary ... #Causes #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... intravascular hemolysis ... agglutinin #disease #hemolytic ... #anemia #hematology
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Algorithm Primary ... Lymphoproliferative Disorders ... Leukemia (CML) - Hemolytic ... Anemia - Others ... #causes
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Algorithm Low ... • Bleeding • Hemolysis ... #Algorithm #Causes ... #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Algorithm Infectious ... Myeloproliferative disorders ... Serum Sickness Hemolytic ... #Algorithm #Causes ... #Hematology
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