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hepatology lfts transaminitis algorithm blood product reactions abscess acute adultonset arterial causes chemistry children cholestatic dermatology dili disease drug embolism
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Injury ... more specific for hepatic ... Transaminitis #diagnosis ... #differential # ... hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... Diagnosis Framework ... injury) • Ischemic ... ) • Non-hepatic ... #Diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Diagnosis Hepatocellular ... Vasculature • Hepatic ... #Injury #Differential ... #Diagnosis #Causes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... Injury: • Hepatic ... #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... #differential # ... Diagnosis #Management ... gastroenterology #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... normal - Hemolysis, NASH ... #Injury #hepatology ... transaminitis #differential ... #diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
replaced by non-hepatic ... disease: > 2 • NASH ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
arthritis, Skin rash ... fraction < 20% Differential ... splenomegaly • Hepatic ... #management #treatment ... #rheumatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Diagnosis Framework ... Syndrome, Ischemic Liver ... Hyperhomocysteinemia - Heparin-induced ... Vasculitis • Injury ... pathophysiology #hematology
Monkeypox What? Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus Viral zoonotic disease that is
Characteristic Rash ... • Fomites • Live ... Umbilification - Rash ... #MPOX #Diagnosis ... #Management #Dermatology
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