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diagnosis rheumatology differential lupus complications druginduced erythematosus management systemic vasculitis acute allergy anaphylaxis anaplasma autoantibodies autoimmune classification comparison coronavirus covid19
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... plugging -> Discoid Rash ... Malar (butterfly) Rash ... #pathophysiology ... #diagnosis #signs
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... NPSLE rare, Malar rash ... constitutional symptoms ... Discontinuation of causal ... : Malar rash, Photosensitivity
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Erythematosus (SLE ... Musculoskeletal Manifestations ... Myopathy (Also caused ... Complications #pathophysiology ... #signs #symptoms
Anaplasma Infection - Anaplasma phagocytophilum Pathophysiology: • Obligate, intracellular bacteria • Transmitted via blacklegged tick —
phagocytophilum Pathophysiology ... within morulae Signs ... and symptoms: ... shaking chills • Rash ... ), cough (30% cases
Extrapulmonary manifestations of COVID-19 • Neurologic: Headaches, Dizziness, Encephalopathy, Guillain-Barré, Ageusia, Myalgia, Anosmia, Stroke • Renal:
Extrapulmonary manifestations ... Gastrointestinal: Diarrhea, Nausea ... , Erythematous rash ... Extrapulmonary #Diagnosis #Signs ... #Symptoms #SARSCOV2
Manifestations of Anaphylaxis by Body System Dermatologic/mucosal - Eyes: periorbital swelling/erythema, injected conjunctiva, tears - Oral mucosa:
Manifestations of ... Skin: urticarial rash ... , morbilliform rash ... Diagnosis #Allergy #Signs ... #Symptoms #Anaphylaxis
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 Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Erythematosus - Diagnosis Manifestations ... 69% - Malar rash ... Lupusreference #SLE ... autoantibodies #signs ... #symptoms #mimickers
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
fatigue Heat Rash ... without neuro manifestations ... Collapse: • Pathophysiology ... → Syncope • Signs ... /Symptoms: - Lightheadedness
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
(28%) • Skin rash ... elevation • Nausea ... nervous system manifestations ... 14%), in which case ... • New onset SLE
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Constitutional symptoms ... NPSLE rare, Malar rash ... is rare in DIL, SCLE-DIL ... constitutional symptoms ... Discontinuation of causal
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