13 results
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
hematuria and/or proteinuria ... /nephritic syndromes ... casts or dysmorphic ... RBCs in urine)? ... #Diagnosis
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... severe cases ... #Nephrology #Diagnosis
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... • Fanconi's syndrome ... sediment - WBC/ ... RBC casts ... #Nephrology #Differential
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
castsDiagnostic ... - Proteinuria ... #Diagnosis #causes ... #urology #nephrology ... #renal #urine #
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... suggestive of nephrotic ... • RBC Casts - ... #Urine #Microscopy ... #nephrology #interpretation
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Mesangiocapillary GN ... • Active Urine ... , RBC casts, +/- ... glomerulopathy, radiation nephritis ... #diagnosis #renal
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
cell/white cell casts ... because nephritic ... #diagnosis #glomerular ... #proteinuria #nephrotic ... #syndrome #nephrology
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... heme-granular casts ... tubulointerstitial nephritis ... Fatty - Nephrotic ... Microscopy #Diagnosis
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
• Drugs • Pulmonary ... GI losses • Renal ... Cirrhosis • Nephrotic ... GFR, AKI/CRF Hormonal ... Hypo-osmolar urine
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
• Drugs • Pulmonary ... GI losses • Renal ... Cirrhosis • Nephrotic ... GFR, AKI/CRF Hormonal ... Hypo-osmolar urine