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diagnosis algorithm anemia workup abnormal atlas morphology transaminitis treatment agglutinin antibody autoimmune bloodcell calculation causes chemistry classification cold disease disorders
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology ... Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... 3) Internal (RBC ... Urobilinogen #Hemolysis ... Diagnosis #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... reticulocytes • Hemolysis ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... Antibody #Autoimmune #Hemolytic
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune hepatitis, PBC ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC ... diagnosis #algorithm #hepatology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... coagulopathy (DIC) #RBC ... #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC ... (hemolysis) • ... #Hepatology #transaminitis
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Pancytopenia - Differential ... Initial Workup: CBC ... reticulocyte count, LFTs ... ↑ Destruction (hemolysis ... Diagnosis #Algorithm #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... anemia, Intrinsic RBC ... Production #Index #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
-100): • Non-hemolytic ... anemia, CKD • Hemolytic ... Spherocytosis, G6PD, PK, HbC ... Non-megaloblastic: Liver ... #Diagnosis #hematology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Ducts - PBC ... Burak @kwburak #LFTs ... Algorithm #diagnosis #hepatology
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