15 results
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Table Warm AIHA ... DAT-negative AIHA ... #AIHA #Differential ... Diagnosis #Table #hematology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
- Differential ... : • Autoimmune ... (AIHAs) • Alloimmune ... #Anemias #Differential ... Diagnosis #Algorithm #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Immune-Mediated • Warm AIHA ... • Cold AIHA ... • Drug-induced AIHA ... Complement-Mediated • Cold AIHA ... Algorithm #Causes #Hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
1) DIAGNOSE AIHA ... ↑ LDH • Anti-RBC ... • Blood smear: Differential ... screening 3) TREAT AIHA ... #diagnosis #management
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... Warm AIHA: 1) Steroids ... #Autoimmune #Hemolytic ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
(AIHA) "Warm" ( ... (AIHA)"Cold" (usually ... • Intrinsic RBC ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... : Warm AIHA, Cold ... AIHA, Transfusion ... Diagnosis #hematology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... been reported (eg AIH-PBC ... If suspected, AIH ... #Hepatitis #AIH ... #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Liver Enzymes - Differential ... • Ischemia • Autoimmune ... • Drugs • AIH ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Liver Injury - Differential ... Celiac disease • Autoimmune ... : Autoimmune hepatitis ... #differential # ... diagnosis #algorithm #hepatology