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differential management hematology algorithm medications nephrology treatment oncology table comparison criticalcare drug druginduced drugs cardiology deficiency endocrinology hepatology lupus pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... leukemias > 20% ... -> AML: Blast crises ... Neutrophils • Immature/Myeloblasts ... Hematology #Oncology #Diagnosis
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
- Differential Diagnosis ... (AML) • Chronic ... Hypercalcemia - Drug-Induced ... #Differential #Diagnosis ... endocrinology #causes
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome - Causes ... Plasmapheresis - Leukemia ... Hydroxyurea - Leukemia ... hyperleukocytosis (AML ... #Differential #Diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... - Differential Diagnosis ... Chronic Myelogenous Leukemia ... following EtOH induced ... #Algorithm #Causes
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
- Differential Diagnosis ... (CML) - associated ... Chickenpox Other Causes ... #Differential #Diagnosis ... #causes #hematology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
- Differential Diagnosis ... • Lymphoma • Leukemia ... Hepatitis • Drug Induced ... #Differential #Diagnosis ... #Algorithm #Causes
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
- Differential Diagnosis ... • Eosinophilic Leukemia ... ), Heme malig (AML ... Hypersensitivity (DRESS, drug-induced ... #Differential #Diagnosis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential Diagnosis ... Chronic myeloid leukemia ... (CML) - Dr. ... #Causes #hematology
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
- Differential Diagnosis ... Ovarian - Leukemia ... Lymphoma: NHL, CML ... #Differential #Diagnosis ... #Algorithm #causes
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
- Differential Diagnosis ... Dark urine • 1ml ... liter urine can induce ... → Diagnostic of ... Intervention • Exercise induced
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