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causes classification macrocytic platelets agglutinin approach atlas basophilia basophils bloodcell cancer cold disease elevatedmcv gap globulin hodgkins leukemia lymphoma macrocytosis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
): • Acute infection ... malignancies • Anemia ... iron deficiency, hemolysis ... MF) • Chronic myeloid ... #hematology #secondary
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Differential Diagnosis ... Reactive: • Anemia ... /blood loss (Fe ... Myelofibrosis • Chronic Myeloid ... #Platelets #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... Diagnosis Algorithm ... Acute • Myloid ... #Disorders #hematology ... #Diagnosis #Algorithm
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... : Acute blood loss ... , Acute hemolysis ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... Infectious: • Acute ... • Rheumatic disorders ... Diagnosis #Algorithm ... #Causes #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... younger pts) Differential ... Diagnosis Monoclonal ... significance (MGUS), CLL, Myeloma ... #anemia #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm ... Blood Loss ... • Acute Bleed - ... #Diagnosis #Algorithm ... #Causes #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... disease, McLeod blood ... Unstable hemoglobin disorders ... RBC #Morphology #differential ... #diagnosis #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... Myeloproliferative Disorders ... : • Chronic myeloid ... myeloid leukemia ... #hematology #basophils
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Diagnosis Algorithm ... Normal Blood Smear ... • Small Bowel Disorder ... #Diagnosis #Algorithm ... #Causes #Hematology
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