14 results
diagnosis oncology gammopathy differential clinical disease multiplemyeloma rheumatology significance workup agglutinin algorithm amyloidosis arthritis autoinflammatory biopsy cardiology cell cold complications
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
protein level <3 ... No evidence of anemia ... protein level ( ... insufficiency, Anemia ... protein level <
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
patients with monoclonal ... (IgG type, M- protein ... concerning for myeloma ... #monoclonal #gammopathy ... diagnosis #management #hematology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Features: POEMS, AL amyloid ... deposits: Ig-related amyloid ... #Significance #MGUS ... Differential #Diagnosis #hematology
Amyloidosis Diagnosis 1) Patient presentation • Cardiac-specific signs of amyloidosis: Diastolic heart failure, Heart failure with preserved
and diarrhea, Monoclonal ... significance (MGUS ... neuropathy, atypical MGUS ... or smoldering myeloma ... protein, Abnormal
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Protein/M Component ... • MM • WM • MGUS ... POEMS (Sclerotic myeloma ... (-) hemolytic anemia ... Paraproteinemias #Hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma ... 40 ml/min A - Anemia ... gamma gap (total protein ... #Gammopathies #MGUS ... #diagnosis #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... Abnormalities: macrocytic anemia ... criteria for 1) hematologic ... peripheral blood myeloid ... cells NEJM Review
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... significance (MGUS ... ), CLL, Myeloma ... #hematology #diagnosis
Indications for Serum Protein Electrophoresis (SPEP) • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
Suspected multiple myeloma ... • New-onset anemia ... which multiple myeloma ... • Unexplained pathologic ... Electrophoresis #SPEP #Hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Significance (MGUS ... Antibodies against myelin-associated ... glycoprotein (MAG) in myelin ... high-risk situations #MGUS ... Complications #diagnosis #hematology
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