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VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... thrombocytopenia, multiple myeloma ... myelodysplastic syndrome ... conditions - multiple myeloma ... peripheral blood myeloid
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
myelodysplastic syndrome ... • Myeloid hemopathy ... dermatosis: Sweet's syndrome ... myelodysplastic #syndrome
Priapism Secondary Causes: Medications- intracavernosal injections, anticoagulants, PDE5 inhibitors, alpha blockers, methylphenidate, cocaine Any hyperviscosity syndrome (SCD, leukemia,
hyperviscosity syndrome ... SCD, leukemia, myeloma ... or are zebras (…amyloid
Causes of Hypercalcemia Parathyroid hormone–dependent Primary hyperparathyroidism Familial hypocalciuric hypercalcemia Lithium-associated Tertiary hyperparathyroidism Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
metastases and multiple myeloma ... Other humoral syndromes ... disease - Williams syndrome ... intoxication, milk-alkali syndrome
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 Causes of Splenic Infarcts - Differential Diagnosis • Myeloid disorders: Myeloproliferative neoplasms (myelofibrosis, polycythemia vera, essential
Differential Diagnosis • Myeloid ... Myelodysplastic syndromes ... Antiphospholipid syndrome
Workup of Hypercalcemia - Differential Diagnosis Algorithm High or Normal PTH: • Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia,
VitD: Multiple Myeloma ... disease, Milk Alkali Syndrome ... disease, Viral Syndromes
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Myelodysplastic syndrome ... MF) • Chronic myeloid
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome ... Plasmapheresis - Multiple myeloma ... Hyperviscosity #Syndrome
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
Paraprotein-associated (POEMS syndrome ... , myeloma, secondary ... amyloid), Paraneoplastic
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
lymphoma, melanoma, myeloma ... Vascular: Budd-chiari syndrome ... Sinusoidal obstruction syndrome
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