42 results
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
onset of muscle symptoms ... any time during treatment ... , hypothyroid-induced ... after DC Statin Treatment ... diagnosis #management #treatment
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
Hypothyroid Myopathy ... Symmetric, proximal myopathy ... Rhabdomyolysis (rare) #Hypothyroid ... #Myopathy #pathophysiology ... #signs #symptoms
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
varied clinical symptoms ... There are several symptoms ... Myopathy due to ... clinical #video #neurology ... endocrinology #hypothyroid
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
Hypothyroidism – symptoms ... Symptoms: Tiredness ... hypertrophy, Proximal myopathy ... reflexes, Anaemia #Hypothyroid ... Features #Signs #Symptoms
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... less systemic symptoms ... and anti-HMGCR myopathy ... after 2 years of treatment
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
findings: • Symptoms ... - Radiation myelopathy ... - Radiation myelopathy ... response LMN Symptoms ... disorders #diagnosis #neurology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
proximal weakness Myopathy ... mediated necrotizing myopathy ... Endocrinopathies: Hypothyroid ... aminotransferases • Serology ... Differential #Diagnosis #neurology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Aseptic Meningitis, Myelopathy ... Puncture, EEG Treatment ... Erythematosus #SLE #CNS #neurology ... diagnosis #management #treatment
Hyponatremia with Severe Symptoms - Management Algorithm with Hypertonic Saline
The goal of acute management is to
Hyponatremia with Severe Symptoms ... 5 or stop the symptoms ... Management #Algorithm #treatment ... Hypertonic #Saline #nephrology
Myoedema on Physical Exam
Myoedema (or "mounding"): A sign of Hypothyroidism, refers to a small lump rising
characteristic of hypothyroid ... myopathy, lasts ... PhysicalExam #clinical #neurology