17 results
diagnosis differential management myopathy vasculitis erythematosus hematology myositis sle systemic autoimmune classification monoclonal myopathies oncology treatment algorithm cerebritis champs clinical
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
symmetric muscle weakness ... symmetric muscle weakness ... Anti-retrovirals, Gemcitabine Lupus ... uncommon 5-15% of lupus ... diagnosis #comparison #rheumatology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... 80%) - Proximal Weakness ... femoral heads • Myopathy ... #Systemic #Lupus ... Complications #pathophysiology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... purpura, Arthralgia, Weakness ... syndrome in 80% ... (e.g. systemic lupus ... classification #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... Demyelinating Syndrome ... Aseptic Meningitis, Myelopathy ... Disease, PRES Pathophysiology ... CNS #neurology #rheumatology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... level of muscle weakness ... anti-synthetase syndrome ... have significant weakness ... Myositis #diagnosis #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Mnemonic C - Cryoglobulinemia ... antiphospholipid syndrome ... S - Systemic Lupus ... #differential #hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Post-strep GN, Lupus ... Nephritis, Cryoglobulinemia ... diagnosis #algorithm #rheumatology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
POEMS, AL amyloid, Cryoglobulinemia ... late-onset nemaline myopathy ... capillary leak syndrome ... • Schnitzler syndrome ... • Cryoglobulinemia
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... Guillain-Barré syndrome ... GBS), systemic lupus ... antisynthetase syndrome
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
late-onset nemaline myopathy ... Immunotactoid GN & Cryoglobulinemic ... WM: Vasculitis (Cryoglobulinemic ... to cold IgG • Lupus ... Paraproteinemias #Hematology
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