17 results
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Weakness • Spinal ... Poliomyelitis, Guillain-Barre ... Mitochondrial myopathy ... #diagnosis #neurology
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... , Guillain-Barré ... syndrome (GBS), ... antisynthetase syndrome
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
Hypothyroidism – symptoms ... and signs. ... Symptoms: Tiredness ... Carpal timel syndrome ... hypertrophy, Proximal myopathy
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... less systemic symptoms ... , holster sign, ... anti-synthetase syndrome ... and anti-HMGCR myopathy
NINDS Diagnostic Criteria for Guillain Barre Syndrome 
Features Required for Guillain-Barré Syndrome:
 • Progressive muscle weakness
muscle weakness ... , Mild sensory symptoms ... or signs, Cranial ... nervous system signs ... #criteria #neurology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
80%) - Proximal Weakness ... femoral heads • Myopathy ... (Also caused by ... pathophysiology #signs ... #symptoms #diagnosis
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Causes of Peripheral ... Lambert-Eaton Myasthenic Syndrome ... • Congenital Myopathy ... #Neurology #Differential ... Diagnosis #Algorithm #Causes
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
is a clinical syndrome ... and scaly skin, myopathy ... Myopathy due to ... reflex hammer, caused ... clinical #video #neurology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... Lack of UMN/LMN signs ... Myopathy: ... mediated necrotizing myopathy ... Differential #Diagnosis #neurology
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
and signs below ... Non-compressive Spinal Cord Causes ... - Radiation myelopathy ... - Radiation myelopathy ... MCTD, Sjogren syndrome