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diagnosis hematology management differential algorithm anemia blood classification lupus product reactions sle addisons adrenal ana anca antibody antineutrophil antinuclear antinxp2
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... scleroderma) - Anti-Scl ... seen in 30—70% of cases ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Corpuscular Volume (MCV ... B12 - Anti-IF Antibodies ... B12 - Anti-IF Antibodies ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... anti-phospholipid antibodies ... changes), high MCV ... patients if the cause ... #Workup #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Corpuscular Volume (MCV ... Renal Disease, Liver ... Diagnosis #Algorithm #Causes ... #Hematology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
probably < 1500ng/mL ... suspected) • In case ... • Special cases ... (e.g. renal failure ... Measurement #SLE #rheumatology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
dL the ULN R - Renal ... /dL or CC < 40 ml ... Causes of false- ... amyloidosis Other causes ... MGUS #diagnosis #hematology
Primary Adrenal Insufficiency Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
aldosterone Causes ... Lung cancer • Renal ... 21-Hydroxylase Antibodies ... 21-hydroxylase antibodies ... Administer 250 mcg
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Corpuscular Volume (MCV ... Reticulocytosis • Renal ... Diagnosis #Algorithm #Causes ... #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Bleeding (64%) • Renal ... HIT: Heparin-PF4 antibodies ... Treat primary cause ... Coagulation #diagnosis #causes ... treatment #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Rh) & recipient antibodies ... , DIC, hypoTN, renal ... Causes purpura & ... TRALI): Leading cause ... diagnosis #management #hematology
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