15 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... scleroderma) - Anti-Scl ... polyangiitis without renal ... #Antinuclear #Antibody ... antibodies #diagnosis #rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
Discoid Rash A Antinuclear ... Antibody (ANA) ... Arthritis R Renal ... erythematosus #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... Smith, Sm/RNP, Scl ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Erythematosus - Summary Antinuclear ... (ANA) - 95% - Initial ... severe disease & renal ... Ann Marie Kumfer ... Summary #diagnosis #rheumatology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
dL the ULN R - Renal ... /dL or CC < 40 ml ... M spike: • CML ... diseases, CML, ... MGUS #diagnosis #hematology
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
Renal involvement ... Combined decr of C3 and ... /min • <60 mL/ ... TerrierBen #Renal ... Vasculitis #Management #Rheumatology
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
concentration: > 750ng/mL ... and probably < ... 1500ng/mL • Non-adherence ... Special cases (e.g. renal ... Measurement #SLE #rheumatology
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
Retroperitoneum and ... aorta • Head and ... pancreas, biliary, renal ... autoantibodies (antinuclear ... workup #treatment #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
disease (panuveitis, retinal ... aseptic meningitis), MCC ... involvement (uveitis or retinal ... Ocular: Giant retinal ... signs #symptoms #rheumatology
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
in non-muscle myosin ... renal failure ... vWF, factor V, and ... myelofibrosis and ... differential #diagnosis #hematology