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diagnosis hematology ttp microangiopathy rheumatology algorithm arterial causes intravascular management thrombocytopenic treatment venous anemia clots coagulation comparison cryofibrinogenemia dic disseminated
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table • Thrombotic Thrombocytopenic Purpura (TTP)
Thrombotic Microangiopathies ... - Primary Thrombotic ... Diagnosis Table • Thrombotic ... Thrombocytopenic ... Purpura (TTP)
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
TTP/HUS indicates ... thrombotic thrombocytopenic ... purpura/hemolytic ... , Hematology 2012 ... #Diagnosis #Differential
Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
Thrombotic Microangiopathy ... Often hard to differentiate ... testing for TTP #Thrombotic ... #purpura #TTP # ... Diagnosis #Table #Hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Diagnosis of TTP: • Rare and severe, ADAMTS13 deficiency • Autoimmune
Treatment of Thrombotic ... Thrombocytopenic ... Purpura (TTP) ... from other TMA: Thrombotic ... Cauchois #TTP Thrombotic
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Venous Thrombosis ... vs Arterial Thrombosis ... Hematological: - HIT ... Heparin-induced thrombocytopenia ... other causes of purpura
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Arterial and Venous Thrombosis ... TTP - Arterial thrombosis ... sites of venous thrombosis ... - MAHA: TTP, HUS ... Arterial #Venous #Thrombosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
- MAHA: TTP/HUS ... - bleeding or thrombosis ... deficiency) • HIT ... antibodies/SRA - + Thrombosis ... presence of large thrombosis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... : • DIC, TTP/HUS ... necrosis) • VIT ... #Differential # ... #nonpalpable #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
syndrome - Thrombotic ... microangiopathy: Thrombotic ... thrombocytopenic ... purpura (TTP), ... uremic syndrome (HUS
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
Thrombotic Microangiopathy ... triad of MAHA + thrombocytopenia ... association of TMA and HIV ... @AnnKumfer #Thrombotic ... Microangiopathy #TMAs #hematology
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