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diagnosis causes hematology algorithm anemia peds extravascular fever hemolysis agglutinin bruising children classification cold disease floppy hypotonic immunecompromised immunocompromised infant
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Mycoplasma pneumoniae infection ... spherocytosis) • Infections ... #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
and Intravascular ... Hemolysis - Differential ... circulation - Infections ... Differential #Diagnosis ... Algorithm #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... drug induced • Infections ... IVIG infusion Intravascular ... classification #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Due to Viral infection ... Diagnosis: • hemolytic ... younger pts) Differential ... the RBCs causing intravascular ... #anemia #hematology
Causes of Hypotonic Infant (Floppy Newborn) - Differential Diagnosis Algorithm Central Nervous System - Decreased LOC, Axial
Floppy Newborn) - Differential ... Hemorrhage • CNS Infection ... Hematoma • Abscess ... • Congenital Myotonic ... #Causes #Peds #Pediatrics
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - Differential ... • Abscess, bacteremia ... syndrome • Cyclic neutropenia ... with profound hemolysis ... Fever #Patterns #Differential
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Immunocompromised Host - Differential ... Neutropenia or ... • Abscess Formation ... ImmuneCompromised #Differential ... Algorithm #Causes #Hematology
Pyogenic liver abscess in children Common bacterial causes in children: • S.aureus • Strep spp • Enteric
Pseudomonas Sources of infection ... contiguous focus of infection ... #pediatrics #children ... #peds #differential ... #diagnosis #hepatology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Non-immune - Haemolytic ... (disseminated intravascular ... and other severe infections ... #Causes #peds #pediatrics ... #diagnosis #differential
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