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diagnosis hematology anemia causes algorithm hemolysis classification extravascular injury mcv patterns peds purpura abscess agglutinin atlas bruising children cold dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Mycoplasma pneumoniae infection ... spherocytosis) • Infections ... #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
and Intravascular ... Hemolysis - Differential ... circulation - Infections ... Differential #Diagnosis ... Algorithm #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Extrinsic Causes: • Liver ... drug induced • Infections ... IVIG infusion Intravascular
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... , Disseminated intravascular ... key #diagnosis #differential ... #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Approach to Anemia - Differential ... -100): • Non-hemolytic ... Macroangiopathic, Infections ... Non-megaloblastic: Liver ... #Diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Due to Viral infection ... Diagnosis: • hemolytic ... younger pts) Differential ... the RBCs causing intravascular ... #anemia #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... • Bleeding • Hemolysis ... Renal Disease, Liver ... Inflammation, Chronic Infection ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects, Drugs, Liver ... Internal (RBC) - Infections ... #Differential # ... Diagnosis #hematology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 10-20x normal - Infection ... 2-5x normal - Hemolysis ... #Injury #hepatology ... transaminitis #differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Injury: • Infectious ... Bilirubin: RBC (hemolysis ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
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