66 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... involvement: Anti-GBM Disease ... Pauci-immune mediated (Negative ... diagnosis #algorithm #rheumatology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
ULN R - Renal disease ... Causes of false- ... negative SPEP: ... amyloidosis Other causes ... MGUS #diagnosis #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... Positive in 60-80% of cases ... pANCA anti-MPO - Negative ... Evolution: Chronic disease ... #Summary #rheumatology
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm
Relative - Normal RBC Mass / Decreased Plasma Volume
Causes of Polycythemia ... Diagnosis Algorithm Relative ... Cyanotic Heart Disease ... Diagnosis #Algorithm #Causes ... #Hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
levels >1g/L • Negative ... cryoglobulins • Negative ... causes of secondary ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
for refractory disease ... Anticoagulation (case ... by case) • Surgery ... Syndrome #Treatment #management ... #pharmacology #rheumatology
Graves Disease - Autoimmune Hyperthyroidism
Epidemiology: Most common cause of hyperthyroidism, Incidence peaks at 30-50
Diagnosis: 
1 )
Graves Disease - ... Epidemiology: Most common cause ... antibodies 3) If 2 is negative ... UTSWIMchief #Graves #Disease ... Hyperthyroidism #diagnosis #management
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
vasculitis - Diagnosis, causes ... and management ... with refractory disease ... Cryoglobulinemia #Vasculitis #Rheumatology ... Cryoglobulinemic #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... • Autoimmune diseases ... Adult-onset Still disease ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... , PRES Pathophysiology ... autoantibodies that will cause ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management