59 results
Nephron Remodeling as a Mechanism of Diuretic Resistance. When high doses of loop diuretics are used
Nephron Remodeling ... basis, the distal nephron ... of the distal nephron ... Pathophysiology #Nephro ... #IM #LoopDiuretic
Mechanisms of Loop Diuretic Action and Resistance. Panel A, loop diuretics circulate bound to protein. As
Mechanisms of Loop Diuretic ... Panel A, loop diuretics ... shown in Panel C, diuretics ... Pathophysiology #Nephro ... #IM #LoopDiuretic
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... Metolazone Loop diuretics ... loss through the nephron ... loop #thiazide #classes
Renal tubular acidosis (RTA): refers to a group of conditions all of which cause the same
conditions all of which cause ... different types/causes ... Diagnosis #IM #Nephro
Hyperuricemia: Pathogenesis and Complications

 - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
arteriole in the nephron ... dose salicylates, diuretics ... tubule in the nephron ... blood into the nephron ... Release of purine bases
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Causes of Hyponatremia ... Differential Diagnosis Algorithm ... , Diuretic excess ... Ketonuria, Osmotic diuresis ... #Causes #nephrology
Hyponatremia Diagnosis Algorithm
UOsm ≥ POsm - Vasopressin-Dependent
 • UNa < 20 mEq/L - Appropriate (↓ EABV)
Hyponatremia Diagnosis Algorithm ... Helbert Rondon, MD @NephroMD ... #differential #algorithm ... #causes #nephrology
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... organic acids and bases ... acid and most diuretics ... vasopressin control #Nephron
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Causes of High-anion ... Metabolic Acidosis Causes ... and chronic) Causes ... Generalized distal nephron ... differential #diagnosis #causes
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... Differential Diagnosis Algorithm ... especially thiazide diuretics ... Differential #Diagnosis #Algorithm ... #Causes