14 results
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Causes of Hypernatremia ... - Differential ... insipidusNephrogenic ... diabetes insipidus ... #sodium #high
Hypernatremia Differential Diagnosis Algorithm - Diabetes Insipidus Workup

Step #1 - Consider the history
Step #2 - Assess
Hypernatremia Differential ... Diagnosis Algorithm - Diabetes ... history Step #2 ... #Management #Algorithm ... #Sodium #nephrology
Etiologies of Hypernatremia - Differential Diagnosis
GI losses / Insensible losses
Sodium Overload
Transcellular Movement of Water
Central Diabetes Insipidus
- Differential ... Insensible losses Sodium ... Insipidus (Decr ... Diabetes Insipidus ... Diagnosis #Table
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
renal mechanism 2) ... • Euvolemic: Diabetes ... insipidus (central ... or nephrogenic) ... #sodium
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
or neurogenic diabetes ... diabetes insipidus ... mutations in AQP-2 ... #Diabetes #Insipidus ... #Diagnosis #Differential
Hypernatremia - Differential Diagnosis and Treatment
Hypernatremia is almost always due to unreplaced water loss (free water
, Dehydration: neurologic ... water unavailable 2) ... post-obstructive 3) Diabetes ... Insipidus: neurogenic ... #nephrology #sodium
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
cell epithelial sodium ... of epithelial sodium ... diabetes insipidus ... #Diagnosis #Differential ... #Table
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
- Differential ... water loss, Serum Sodium ... 300 mmol/kg • Diabetes ... Insipidus Hypodipsia ... #Nephrology #Differential
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
irrigation • Management ... diabetes insipidus ... diabetes insipidus ... and euvolemic hyponatremia ... #Medications #Table
Primary Polydipsia
Definition: Excessive volitional water intake
Epidemiology:
 • 6-20% of patients with psychiatric disorders - Most commonly
occurs in only 2- ... insipidus Differential ... , Urine Sodium ... Polydipsia #diagnosis #management ... #nephrology