23 results
Hypernatremia Differential Diagnosis Algorithm - Diabetes Insipidus Workup

Step #1 - Consider the history
Step #2 - Assess
Hypernatremia Differential ... history Step #2 ... #Management #Algorithm ... #Sodium #nephrology ... #insipidus #DI
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Causes of Hypernatremia ... - Differential ... • Nephrogenic ... Diagnosis #Causes #nephrology ... #sodium #high
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Differential Diagnosis ... renal mechanism 2) ... Euvolemic: Diabetes insipidus ... Workup #Algorithm #nephrology ... #sodium
Hypernatremia - Differential Diagnosis and Treatment
Hypernatremia is almost always due to unreplaced water loss (free water
urine osm (in DI ... , Dehydration: neurologic ... water unavailable 2) ... : neurogenic, nephrogenic ... #nephrology #sodium
Central vs Nephrogenic Diabetes Insipidus - Desmopressin Challenge
Give desmopressin (intranasal, SQ, IV) and monitor UOsm every
Diabetes Insipidus ... 30 minutes over 2 ... #Diabetes #Insipidus ... #DI #Desmopressin ... Challenge #diagnosis #nephrology
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
Causes of Hypernatremia ... - Differential ... water loss, Serum Sodium ... kg • Diabetes Insipidus ... #Nephrology #Differential
Two-step Copeptin algorithm for differential diagnosis of Diabetes Insipidus (DI)

Baseline Copeptin < 21.4 pmol/L:
 • Arginine-stimulated
algorithm for differential ... prior thirsting) → Nephrogenic ... Insipidus #DI #algorithm ... #copeptin #nephrology ... #differential #
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Hyponatremia Differential ... Serum Osmolarity 2) ... Osmolarity 3) Urine Sodium ... #Differential # ... Diagnosis #Algorithm #nephrology
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
Central or neurogenic ... Surgery, Idiopathic Nephrogenic ... mutations in AQP-2 ... Classification #Types #Nephrology ... #Diagnosis #Differential
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
cell epithelial sodium ... of epithelial sodium ... diabetes insipidus ... Defects #Kidney #Nephrology ... #Diagnosis #Differential