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diagnosis differential hematology causes management oncology abscess approach bandemia cbc disorders erythematosus extravascular hematololgy hemolysis intravascular lung lupus lymphomas lymphoproliferative
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Definition • Pathophysiology ... Expectation • Rx Algorithm ... #Anemia #diagnosis ... #oncology #hematololgy
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Differential Diagnosis Algorithm ... • Marrow Aplasia ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... RBC Production - Normal ... Deficiency • Aplastic ... #Classification ... #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... syndrome (MDS) (normal ... megakaryocytes and a normal ... anemia) Labs
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Differential Diagnosis Algorithm ... Megakaryopoiesis • Aplastic ... Anemia • Toxic ... Prosthetic Heart Valve ... #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Differential Diagnosis Algorithm ... Chronic Disease Normal ... #MCV #Classification ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Drug-induced AIHA - Abnormal ... immune-complex hemolytic anemia ... Prosthetic heart valves ... #Causes #Hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% ... Band neutrophils normally ... appreciate the value ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... can have extra nodal ... Lymphoproliferative #Disorders #Classification ... #pathophysiology ... #Hematology #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
sedimentation rate + Normal ... Skin Disease Classification ... Cytopenias • Cardiac valve ... lymphopenia, low PLT • Anemia ... flares • CRP normal
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