33 results
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Investigation of Abnormal ... PT - Prolonged aPTT ... #Coagulation #Abnormal ... #APTT #Laboratory ... #Hematology #Diagnosis
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Prolonged PT (INR), Normal ... PTT, Normal PT ... , Normal PT (INR ... #PPT #PT #INR #Differential ... Algorithm #Causes #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
GI. uterine) Laboratory ... • Normal platelet ... PT/INR • Normal ... aPTT (prolonged ... Disease #Diagnosis #Hematology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
an inhibitor of normal ... PT and/or aPTT) ... Study #diagnosis #hematology ... pathophysiology #hematology ... #laboratory
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Microangiopathy (TMA) - Differential ... antiglobulin test, PT/aPTT ... hemosiderin • PT/aPTT ... normal • DAT ... Management #Algorithm #hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Thromboplastin Time (PTT ... inhibitor • Liver ... Thromboplastin Time (PTT ... Thromboplastin #laboratory ... #hematology #diagnosis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Volume (MCV) - Differential ... WBCs - Normal ... Liver Function ... #elevatedMCV #Differential ... Algorithm #Causes #Hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Expected: Low (or normal ... aggregation PT, aPTT ... factors, Can be normal ... Scoring #diagnosis #hematology ... #laboratory
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... amyloidosis #Abnormal ... Causes #diagnosis #differential ... #hematology #coagulation
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects, Drugs, Liver ... Hypophostphatemia Laboratory ... Blood Smear ↑ abnormal ... #Diagnosis #hematology