31 results
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
anemia, Chronic ... disease anemia ... myeloma Rouleaux: Chronic ... Inflammatory Diseases ... differential #diagnosis #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
80 fL) • Iron Deficiency ... of Chronic Disease ... of Chronic Disease ... • Folate Deficiency ... Algorithm #Causes #Hematology
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
Algorithm - Iron deficiency ... of chronic inflammation ... - Anemia of chronic ... kidney disease ... and/or folate deficiency
Iron Deficiency Anemia vs Anemia of Chronic Disease - Laboratory Testing

SUMMARY:
 - RDW, FEP, serum iron,
Anemia vs Anemia ... of Chronic Disease ... in underlying inflammatory ... #Anemia #Chronic ... #Disease #Laboratory
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
of chronic kidney ... disease, Acute ... , Folate deficiency ... Alcohol use, Liver disease ... diagnosis #causes #hematology
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
Nutritional: DiabetesB12 deficiency ... , Uremia/ESRD, Hypothyroidism ... , Leprosy • Inflammatory ... , Sarcoidosis, Amyloidosis ... diagnosis #causes #neurology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
: • Acute or Chronic ... Inflammatory: ... disorders • Celiac disease ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... • B12/Folate Deficiency ... • Anemia of Chronic ... Disease • Marrow ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Congenital Diseases ... : • GATA2 deficiency ... • Fanconi’s anemia ... • Lymphoma Inflammatory ... and Autoimmune Diseases
Causes of Iron Deficiency
 • Inadequate Intake: Vegetarian/vegan diet, Malnutrition
 • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Elite athletes • Chronic ... Loss (without anaemia ... • Inflammatory ... ) #Iron #Deficiency