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management differential rheumatology hematology microbiology causes adultonset chagas hemophagocytic hlh lymphohistiocytosis oncology pulmonary trypanosomiasis aids american aosd arthritis chronic classification
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... triad: Fever, Arthralgia ... : • Infectious ... #Disease #diagnosis ... #management #treatment
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
Adult Onset Still's ... criteria: - Fever ... with concomitant fever ... #AdultOnset #Stills ... #Criteria #Diagnosis
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Differential Diagnosis ... leishmaniasis • Adult ... : • Still's disease ... Causes: • Still's ... #Differential #Diagnosis
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Disease (AOSD) ... : High spiking fever ... #AdultOnset #Stills ... #Disease #AOSD
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
- Differential Diagnosis ... • Infection: ... , Sarcoidosis, Adult ... onset Still's disease ... #Differential #Diagnosis
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... mL Gf consider MAS ... Treatment - Mild ... : NSAIDS Treatment ... #onset #Stills
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... • Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease, ... #management #treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... Still disease ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis
Tularemia - Diagnosis and Management Summary Francisella tularensis - Aerobic fastidious gram-negative Coccobacillus - Zoonotic Infection •
Coccobacillus - Zoonotic Infection ... Ulceroglandular: Fever ... More common in adults ... : • Severe Disease ... #infectiousdiseases
Hantavirus Pathogen: Hantavirus - Rodents are the primary reservoir Transmission: • Shed in the urine, feces, saliva of
common route of infection ... • Prodrome: fever ... , chills, myalgias ... +/- diarrhea Diagnosis ... #microbiology #infectiousdiseases
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