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differential treatment causes rheumatology algorithm hemophagocytic hlh hyponatremia lymphohistiocytosis activation adultonset apml differentiation disease diuresis diuretics excretion hemeonc mas medications
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Syndrome (MAS) ... arthritis (sJIA) • Adult-onset ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Algorithm Syndrome ... • Neurologic trauma ... • Drugs • Pulmonary ... GI losses • Renal ... #Hyponatremia #Nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Algorithm Syndrome ... • Neurologic trauma ... • Drugs • Pulmonary ... GI losses • Renal ... #Hyponatremia #Nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... Renal Syndromes ... hemosiderin laden macrophages ... #Renal #Syndromes ... #management #treatment
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Complications: MAS ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... with excessive macrophage ... also observed in adults ... #management #treatment ... #hematology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Differential Diagnosis ... Framework and Management ... Rhabdomyolysis: • Trauma ... #Management #causes ... #treatment #nephrology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Imaging: CXR- pulmonary ... Anaphylaxis, Acute Renal ... Differentiation #Syndrome ... #management #hematology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
and Management ... dysregulation: activated macrophages ... , and possibly renal ... Pulmonary: dyspnea ... #Management #Signs
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Agents Regulating Renal ... • Diagnosis of ... irrigation • Management ... Torsemide) • Acute pulmonary ... Excretion #Diuresis #Nephrology
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