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management differential causes syndrome chronic workup algorithm aplastic cll comparison disease hemolytic hodgkins lymphocytic lymphoma mds monoclonal myelodysplastic rheumatology thrombocytosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
: 70 years old, ... cytopenias (usually anemia ... transformation to acute leukemia ... #Management #treatment ... #hematology #oncology
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Warm vs Cold Autoimmune ... Spherocytes • Treatment ... transient hemolysis • Treatment ... BostonChiefs #Warm #Cold ... #hematology #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Chronic Myelogenous Leukemia ... effect following treatment ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Diagnosis: • Pancytopenia ... Treatment: • Consider ... to MDS or acute leukemia ... #diagnosis #management ... #treatment #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... infiltrate any organ ... • Neutropenia, anemia ... microglobulin Treatment ... #oncology #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential Diagnosis ... infection • Solid organ ... malignancies • Anemia ... Chronic myeloid leukemia ... #Causes #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... 5) Symptoms of anemia ... marrow failure with anemia ... #oncology #hematology ... #hemeonc #diagnosis
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Iron Deficiency Anemia ... (IDA) Tests: ... Iron #Deficiency #Anemia ... #Fe #diagnosis # ... hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... Test: Donath-Landsteiner ... test #cold # ... #hematology #diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Autoimmune: Warm AIHA, Cold ... Defects: Sickle cell anemia ... Laboratory Tests ... #hematology
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