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management hematology oncology algorithm differential causes infectiousdiseases unknown acromegaly activation acute agglutinin anemia anesthesia anesthesiology apml cancer carcinoma checklist chronic
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
Origin (FUO) - ... Further Workup ... Test for the respective ... udaygulati #FUO ... #workup #diagnosis
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
of Unknown Origin ... Diagnosis • Infection ... Lemierre's syndrome ... tumors: Renal cell ... #Unknown #Origin
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... Lymphadenopathy • Fevers ... microglobulin Treatment ... #workup #oncology ... #hematology
Possible Algorithm for Workup of Fever of Unknown Origin (FUO) Tier 1 Workup: • CBC, comprehensive metabolic
of Fever of Unknown ... Origin (FUO) Tier ... • Additional tests ... #Unknown #Origin ... #Workup #diagnosis
Disseminated Gonococcal Infection - Diagnosis and Management Summary Bacteremic spread of the Gram-negative diplococci Neisseria gonorrhoeae. History
the preferred test ... typically part of the workup ... • Test all patients ... : • Fever, chills ... Purulent Arthritis Syndrome
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
- Nonremitting fever ... Liver function tests ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Symptoms: High fevers ... Test: Donath-Landsteiner ... test #cold # ... hemolytic #anemia #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... • Induce blast cell ... Subacute-Acute: • Common: fever ... Renal Failure Treatment
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary Clinical features - Classic triad (flank pain, hematuria,
Renal Cell Carcinoma ... (RCC) - Diagnosis ... night sweats, fever ... Budd Chiari syndrome ... disease Imaging and Treatment
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... lab signs of end organ ... damage • Treatment ... #TLS #diagnosis ... #management #hematology
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