40 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Cerebrovascular Disease ... #SLE #CNS #neurology ... #rheumatology # ... #management #treatment
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Treatment: • ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... life-threatening • Treatment ... Evolution: Chronic disease ... #Diagnosis #Management
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
central nervous system ... and treatment can ... lupus erythematosus ... BEE #Syndromes #neurology ... #differential #diagnosis
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
suspicion of severe disease ... guidelines General - Systemic ... splenomegaly, abnormal neurology ... #Child #Peds #Pediatrics ... #Diagnosis
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Differential Diaqnoses ... solid cancers • Systemic ... #diagnosis #management ... #treatment #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
months to years) Systemic ... life-threatening • Treatment ... Usual therapeutic management ... Evolution: Chronic disease ... #diagnosis #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Systemic lupus ... lupus erythematosus ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Tularemia - Diagnosis and Management Summary
Francisella tularensis - Aerobic fastidious gram-negative Coccobacillus - Zoonotic Infection
 •
and Management ... • Typhoidal: Systemic ... : Serology (preferred ... : • Severe Disease ... #management #treatment
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... episode (30%) Systemic ... #AOSD #rheumatology ... #diagnosis #management ... #treatment