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AKI in Cirrhosis - Hepatorenal Syndrome Management Algorithm

DOI: 10.1136/bmj.m2687

#AKI #Cirrhosis #Hepatorenal #Syndrome #HRS #Management #Algorithm #nephrology
AKI in Cirrhosis ... - Hepatorenal Syndrome ... #Hepatorenal #Syndrome ... #HRS #Management ... #Algorithm #nephrology
Hepatorenal Syndrome (HRS) - Diagnostic Criteria
HRS-AKI (Acute: previously known as HRS Type 1)
 • ↑ Creatinine
Hepatorenal Syndrome ... in 3 months • Cirrhosis ... No structural kidney ... injury: No proteinuria ... #Hepatorenal #Syndrome
Pharmacological Treatment of Hepatorenal Syndrome (HRS)

Midodrine - Alpha agonist incr blood pressure incr renal perfusion pressure
Syndrome (HRS) ... edgarvlermamd - Nephrology ... amzn.to/34t5DgJ #HRS ... #HepatoRenal #Syndrome ... #Nephrology #Management
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Acute Kidney Injury ... failure (a.k.a. hepatorenal ... syndrome) Intrarenal ... vasculitis - TTP/HUS ... #diagnosis #nephrology
Indications for Albumin for Management of Cirrhosis
 • Large volume paracentesis (>5 liter) - 8g per
of Cirrhosis ... removed • Acute kidney ... injury (≥ 1B) - ... antibiotics • Hepatorenal ... syndrome - 1g/
Hepatorenal Syndrome Diagnosis
 • ↑ in serum Cr of ≥ 0.3mg/dL above baseline
Hepatorenal Syndrome ... (e.g. advanced cirrhosis ... EricsMedicalLectures/ #Hepatorenal ... #Syndrome #diagnosis ... #HRS #nephrology
Hepatorenal Syndrome Treatment
Volume expansion: 
 • Albumin (typical dose = 1g/kg on day 1 +/- day
Hepatorenal Syndrome ... EricsMedicalLectures/ #Hepatorenal ... #Syndrome #Treatment ... #management #HRS ... #nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... Distributive Shock, HRS ... Abdominal Compartment Syndrome ... #AKI #Acute #Kidney ... #Diagnosis #nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... clinical context and signs ... pressure • TTP / HUS ... #Injury #AKI #Workup ... Differential #Diagnosis #nephrology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
causes of Acute Kidney ... Injury AKI - Differential ... calcineurin inhibitors, hepatorenal ... syndrome) • Vascular ... Differential #Diagnosis #nephrology