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Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... IGFIR activates osteoblasts ... GrowthHormone #GH #FeedbackLoop
Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
Bone resorption ... the surface of bone ... from the adjacent bone ... which results in bone ... #Osteoclasts #Bone
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... -> Incr Osteoclasts ... -> Reduced Bone ... Formation, Increased Bone
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... cells activate osteoblasts ... more than osteoclasts ... activate largely osteoclasts
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
cartilaginous matrix by osteoblasts ... forms bony callus ... mos - yrs) • Osteoclast-osteoblast ... coupled bone remodeling ... from GI tract, bone
Skull Bone Anatomy - Facial Bones By @rev.med #Skull #Bones #Anatomy #Facial
Skull Bone Anatomy ... - Facial Bones ... rev.med #Skull #Bones
Humerus Bony Anatomy - Anterior and Posterior Views By @rev.med #Humerus #Bony #Anatomy #MSK #Bone
Humerus Bony Anatomy ... rev.med #Humerus #Bony ... #Anatomy #MSK #Bone
Bisphosphonates for Osteoporosis Treatment or Prevention Bisphosphonates are common medications used in the treatment and prevention
Bisphosophonates inhibit osteoclasts ... turn increase bone
Diagram of different types of bone tumors that can occur around the knee on XRay -
different types of bone ... Simple/unicameral bone ... • Aneurysmal bone ... docskalski #Knee #Bone ... Tumors #Diagnosis #Bony
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
Prolactin #PRL #FeedbackLoop
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