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hematology oncology differential management algorithm aplastic causes myelodysplastic cancer cardiology chronic cll endocarditis infectiousdiseases lymphocytic mimickers mimics myelodysplasia platelets pseudocellulitis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
): • Acute infection ... malignancies • Anemia ... Myelodysplastic syndrome ... Chronic myeloid leukemia ... #Causes #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... (MD) - Diagnosis ... leukemia Management ... Myelodysplastic #Syndrome ... #MDS #Diagnosis
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Treatment: • Consider ... (transfusions, antibiotics ... Can progress to MDS ... or acute leukemia ... #treatment #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... Matthew Ho, MD
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- Overview Who ... Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... myelodysplastic syndrome
Causes of Pseudocellulitis - Differential Diagnosis Framework for Cellulitis Mimics Cellulitis: Deep skin and subcutaneous fat infection Pseudo
Angioedema • Sweet syndrome ... • Gout • Acute ... • Lymphoma • Leukemia ... • Compartment syndrome ... mimickers #Causes #dermatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Myelodysplastic syndromes ... (CML) • Felty Syndrome ... isoniazid) • Antibiotics ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... microglobulin Treatment ... • Richter’s Syndrome ... ’s lymphoma or acute ... • Sezary syndrome
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Sweet Syndrome ... Acute febrile ... dermatosis (Sweets Syndrome ... classical Sweet syndrome ... #diagnosis #dermatology
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