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diagnosis differential management pharmacology diabetes endocrinology algorithm nephrology rheumatology treatment dermatology summary cardiology chronic classification clinical dermatomyositis hyperkalemia pathophysiology photo
GLP-1 Receptor Agonists - Pharmacology Summary Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
Weekly injection (Ozempic ... daily tablet (Rybelsus ... e.g. diarrhea, nausea ... not definitively cause ... Pharmacology #Summary #DM2
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist Dosing: 3 mg daily x 30 days, then 7 mg
Rybelsus (oral semaglutide ... if needed Rybelsus ... the injection Ozempic ... titration schedule as Ozempic ... Rybelsus will be
Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
agent • Does not cause ... mL/minute/1.73 rm2 ... mL/minute/1.73 m2 ... e.g. diarrhea, nausea ... Pharmacology #Summary #DM2
Type 2 Diabetes - Screening, Diagnosis and Management Algorithm Lifestyle Modifications (Diet and Exercise) -> Start
relative with DM2 ... associated with DM ... • Secondary Causes ... Management #algorithm #DM2
GLP-1 Agonists Adlyxin (Lixisenatide) Daily Bydureon (Exenatide ER) Weekly Ozempic (Semaglutide) Weekly Trulicity (Dulaglutide) Weekly Victoza (Liraglutide) Daily
Exenatide ER) Weekly Ozempic ... Dosing #Diabetes #DM2
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... Decrease #Diagnosis #DM2
Secondary Causes of Hypertension - Differential Diagnosis Algorithm Hypertension - BP > 140/90 (>130/80 for DM) Hypertensive urgency
Secondary Causes ... 90 (>130/80 for DM ... end-organ damage or DM ... withdrawal Anatomic Causes ... RAS Metabolic Causes
Causes of Chronic Kidney Disease - Differential Diagnosis Algorithm Decreased kidney function (eGFR < 60 ml/min/1.73 m2)
Causes of Chronic ... 60 ml/min/1.73 m2 ... Sterile pyuria, WBC casts ... Diagnosis #Algorithm #Causes
Causes of Polyneuropathy - Differential Diagnosis Algorithm • Metabolic: DM, Hypothyroidism, CKD, Cirrhosis, Nutritional deficiency •
Causes of Polyneuropathy ... • Metabolic: DM ... Diagnosis #Algorithm #causes
Causes of Hypomagnesemia - Differential Diagnosis Algorithm GI LOSS - FeMg < 2-2.5% or 24h Urine Mg
Causes of Hypomagnesemia ... -1beta, cyclin M2 ... Magnesium #Low #Causes
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