55 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Clinically ... suspect underlying hematologic ... Diagnosis and Treatment ... Matthew Ho, MD PhD ... #HES #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
methotrexate) • Drugs Autoimmune ... CLL • APLA Alloimmune ... Non-lmmune: • HELLP Syndrome ... Vasculitis • Infection ... Algorithm #Causes #Hematology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Diagnosis Algorithm Signs ... Hemolysis: • Autoimmune ... Hypersplenism, Infection ... Matthew Ho, MD PhD ... Diagnosis #Algorithm #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome ... Diagnosis #Algorithm #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... Immune-mediated: - Autoimmune ... idiopathic) - Autoimmune ... differential #diagnosis #hematology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... , holster sign, ... anti-synthetase syndrome ... after 2 years of treatment ... Myositis #diagnosis #rheumatology
Polyarteritis Nodosa (PAN) - Vasculitis Management Algorithm - ACR/VF 2021 Guidelines
 • Severe Disease → Remission
Polyarteritis Nodosa (PAN ... immunosuppressive agent (e.g ... @MithuRheum #PAN ... Vasculitis #Management #Treatment ... Guidelines #algorithm #rheumatology
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... thrombocythemia), Autoimmune ... vonWillebrand #Syndrome ... Diagnosis #Management #treatment ... #hematology #differential
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Thrombocytosis): • Acute infection ... inflammatory disorders (e.g ... . autoimmune, TB ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology
Anterior Non-necrotizing Scleritis - Slit Lamp Ocular Examination

This 57 yo WM reported to clinic complaining of
WM reported to clinic ... history of systemic autoimmune ... patient was sent to rheumatology ... systemic workup and treatment ... #physicalexam #rheumatology