34 results
diagnosis hematology differential management algorithm causes syndrome symptoms classification leukemia workup blood chronic cll elevation intravascular lymphocytic mds myelodysplastic pathophysiology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... #Anemia #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Consider stem cell ... progress to MDS or acute ... Medicine @SCVMCMed #Aplastic
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Neutropenia, anemia ... aplasia • ITP ... ’s lymphoma or acute ... diagnosis #workup #oncology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... Normal RBCs • Acute ... RBCs - Sickle Cells ... , Target Cells
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... RBC) Morphology ... - Sickle cell anemia ... Malignant tumors, Acute ... coagulopathy (DIC) #RBC
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... = funny-shaped cells ... cytopenias (usually anemia ... transformation to acute ... treatment #hematology #oncology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Blood Loss • Acute ... Deficiency • Aplastic ... Anemia • Anemia ... Non-lmmune #Anemia
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... marrow failure: Aplastic ... Index > 3: • Acute ... , Intrinsic RBC ... defects (e.g. sickle cell
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) • Plasmacytoid Dendritic Cells (pDC) Neoplasms • BPDCN • BPDCN
Blastic Plasmacytoid ... Dendritic Cell ... (pDC) Neoplasms ... @ZhuoerXie #Blastic ... Neoplasm #diagnosis #oncology
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
== Decreased RBC ... Hypertriglyceridemia • Uremia ... turnover • Acute ... • Hemolytic anemia ... Splenomegaly, Sickle Cell
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